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CSC-Tübingen PhD Program: Project 02/2025: Unravelling the molecular mode of action of a new antibacterial agent

Topic Description: Antibacterial agents with new chemical core structures and unprecedented targets are urgently needed. Natural products are promising starting points for antibiotic discovery. Also drugs initially developed for human diseases that are not infection-related can have antibacterial properties. The modes of action of such agents will be explored. An assay platform with microbiological, biochemical and genetic mode of action technology is established in the group and will be expanded in the course of the project.

Faculty: Faculty of Science
Institute/Section/Subject: Interfaculty Institute of Microbiology and Infection Medicine, Dept. of Microbial Bioactive Compounds, Subject: microbiology, bacterial physiology, bacterial genetics
Supervising Professors: Prof. Dr. Heike Brötz-Oesterhelt

About the Supervisors: The Brötz-Oesterhelt Lab works with novel antibacterial agents active against multi-resistant bacterial pathogens. Primary focus is on the elucidation of the molecular mechanisms of action. Heike Brötz-Oesterhelt is a microbiologist and has been working in antibacterial drug discovery in the academic and pharmaceutical industry setting. Since 2014 she is full professor for Microbiology at the University of Tübingen heading the Department of Microbial Bioactive Compounds.

Degree: Dr. rer. nat.

Type of the PhD study: Full time at the University of Tuebingen

Requirements for the application:
Required Degrees and Qualifications: MSc in Biology, Biochemistry, Biotechnology or similar; experimental expertise in bacteria, fluorescence microscopy, cloning, protein purification; proficiency in scientific writing in English; team-player
Language Requirements: English C1 in a SELTS (IELTS, PTE, TOEFL) for all parts of the test
Notes:
Exemplary recent publications:
Wex KW, … Brötz-Oesterhelt H. Cell Chem Biol. 2021 doi: 10.1016/j.chembiol.2021.02.022.
Hörömpöli D, … Brötz-Oesterhelt H. Antimicrob Agents Chemother. 2021; doi:10.1128/AAC.00986-20.



For further instructions on how to apply, more information on the program and contact details please see below.

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CSC-Tübingen PhD Program
The China Scholarship Council (CSC) and the University of Tübingen have established a PhD Program which supports Chinese nationals inside and outside of China wishing to carry out all or part of their PhD study in Tübingen.

Aims:

• providing high quality research training to qualified students from Chinese universities
• developing education and research collaborations between the University of Tübingen and Chinese universities and research institutions

Target group:
Excellent postgraduate and doctoral students from the People's Republic of China.

Funding line A - Full time fellowship:

• postgraduate students who want to carry out their complete doctoral studies at the University of Tübingen
• up to 48 months
• degree conferred by the University of Tübingen
• Annual living allowance as prescribed by the Chinese Government (which includes Overseas Student Health Cover)

Funding Line B - Part time fellowship (sandwich model):

• doctoral students who want to carry out their research and studies alternatively at their home universities and the University of Tübingen. They follow a schedule set in advance by both the Chinese supervisors and supervisors at the University of Tübingen
• 6-24 months in Tübingen
• degree conferred by the Chinese home university
• Annual living allowance as prescribed by the Chinese Government (which includes Overseas Student Health Cover) for 6-24 months

Funding for both Funding lines includes:

• Return airfare to Germany
• Visa application fees
• Support for the attendance of international conferences during the second and third year (up to 1000€ granted to successful applicants)

Benefits for both funding lines:

• Tuition waiver
• Option to take German language classes provided by the University of Tübingen during the first year
• Accommodation offered in Tübingen student dormitories depending on availability
• Opportunities to gain additional teaching and research experience as well as economic benefits from the University of Tübingen from the second year onward (depending on the ability of the applicant and the situation of the respective institute)

Application Process:

• Jan 15: Application deadline. Applications must be handed in through the online application system of the University of Tübingen
• by March 10: Successful applicants will be officially informed
• by March 31: Invited applicants have to register with the CSC according to the regulations of the CSC.
• by May 31: Final decisions about the allocation of scholarships will be made by the CSC
• by Oct 1: Program participants arrive in Tübingen
• Successful candidates must return to China upon completion of their studies.

How to Apply:
In order to apply you need to upload the following documents combined in 1 PDF

• Cover/Motivation letter
• CV
• Research proposal (3-5 pages)
• Academic transcripts* (if you have not yet completed your Master's studies, please submit a confirmation of studies and an up-to-date transcript of records)
• Proof of proficient English language skills (i.e. comprehension of a wide range of demanding, longer texts as well as fluent and spontaneous expression allowing a flexible and effective language use for social, academic and professional purposes.) - TOEFL iBT 95 or IELTS 6.5 or equivalent

*List of required Academic transcripts (including official translation into German or English for documents issued in Chinese)
1) Bachelor’s Degree Award Certificate / Bachelor Gradverleihungsurkunde (学士学位证书 xueshi xuewei zhengshu)
2) Bachelor's Degree Certificate/ Abschlusszeugnis (毕业证书 biye zhengshu) für das Bachelorstudium (本科 benke)
3) Transcript of the subjects and marks / Fächer- und Notenübersicht (成绩表 chengjibiao) for your Bachelor’s degree/ für das Bachelorstudium (本科 benke)
4) Master’s Degree Award Certificate / Master-Gradverleihungsurkunde (硕士学位证书 shuoshi xuewei zhengshu)
5) Master’s Degree Certificate/ Abschlusszeugnis für das Masterstudium (硕士研究生毕业证书 shuoshi yanjiusheng biye zhengshu)
6) Transcript of the subjects and marks for your Master’s Degree / Fächer- und Notenübersicht für das Masterstudium (硕士研究生成绩表 shuoshi yanjiusheng chengjibiao)

For questions please contact:
(Ms) Tetyana Tonkoshkur
Dezernat II – Forschung
Internationale Forschungskooperation
+49 7071 29-750005
international.research@uni-tuebingen.de
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