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Korea-Tübingen PhD Program: Project 19/2024:
PhD Project Title: We offer the following PhD project (depending on the interest, background and preferences of the candidate)
(1) Actionable heterogeneity of SASP (senescence-associated secretory phenotype) and surfaceome in hepatocellular carcinoma therapy-induced senescence
(2)Induction of senescence in AML (acute myeloid leukemia) augments NK cell cytotoxicity via inflammasome priming

Topic Description: Innate immunity plays a critical part in the host defense against infection but also in cardiovascular, neurodegenerative, metabolic and malignant diseases. Primary regulators of innate immunity are the so-called pattern recognition receptor (PRRs) which sense internal or external danger and trigger molecular and cellular responses that lead to immunological effector responses. Our lab has a strong track record in PRR signaling pathways and has been contributing insightful results in the areas of microbial recognition, initiation of inflammation and oncogenesis. Recently, we have focused on the effect of cellular senescence induced by therapeutic agents (therapy-induced senescence, TIS) on innate signaling pathways and immune cells in either hepatocellular carcinoma (HCC) or acute myeloid leukemia (AML). Our focus is to investigate how senescence affects well-known PRR pathways, the cellular surfaceome and the way in which senescent tumor cells can be targeted by immunotherapies (e.g. targeting antibodies or NK cells).

Faculty: Faculty of Medicine
Institute/Section/Subject: Interfaculty Institute of Cell Biology, Department of Innate Immunity

Supervising Professor(s): Prof. Alexander N. R. Weber

About the Supervisor(s): Trained biochemist (training in Tübingen, Cambridge UK and Heidelberg) and expert in innate immunity with a focus on the recognition of microbes and endogenous threats by so-called pattern recognition receptors.

Requirements for the application:
Required Degrees: Masters degree (or equivalent) in biological sciences or medicine
Language Requirements: English (IELTS 6,5 or TOEFL equivalent)
Notes: Some research experience in molecular/cellular biology, microbiology/virology, protein biochemistry and/or immunology; high motivation to work independently and as part of a team. We are a dynamic research group with a solid track record, and located in an excellent scientific environment, the Department of Immunology located on the campus of the University of Tübingen, one of Germany’s Excellence Universities. In our well-funded laboratory you would find a friendly, well-connected and international (English-speaking) environment, and a firm commitment to good supervision and professional development.

For further instructions on how to apply, more information on the program and contact details please see below.
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Korea-Tübingen PhD Program
The University of Tübingen have established a PhD Program which supports Korean nationals from partner Universities wishing to carry out all or part of their PhD study in Tübingen.

Cheju National University

Chonbuk National University

Chungnam National University

Ewha Womans University

Hanyang University

Korea University

Pusan National University

Seoul National University

Sogang University

Sookmyung Women's University

Sungkyunkwan University

Yonsei University

Aims:

• providing high quality research training to qualified students from Korean universities
• developing education and research collaborations between the University of Tübingen and Korean universities and research institutions

Target group:
Excellent postgraduate and doctoral students from Korean partner universities who are citizens and permanent residents of the Republic of Korea at the time of application

Application Process:

• December 15: Application deadline. Applications must be handed in through the online application system of the University of Tübingen
• between January 2 and 12: round of interviews in English
• by January 30: Successful applicants will be officially informed and provided letters of admission.
• by April1 or October 1: Program participants arrive in Tübingen

How to Apply:
In order to apply you need to upload the following documents combined in 1 PDF

• Cover/Motivation letter with the description of academic characteristics that qualify you to complete the PhD project successfully
• CV
• Academic transcripts*
• Proof of proficient English language skills - TOEFL iBT 95 or IELTS 6.5 or equivalent

*List of required Academic transcripts (including official translation into German or English for documents issued in Korean)
1) Bachelor’s Degree Award Certificate / Bachelor Gradverleihungsurkunde
2) Transcript of the subjects and marks / Fächer- und Notenübersicht for your Bachelor’s degree/ für das Bachelorstudium
3) Master’s Degree Award Certificate / Master-Gradverleihungsurkunde
4) Transcript of the subjects and marks for your Master’s Degree / Fächer- und Notenübersicht für das Masterstudium

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